Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia.
Patients with B cell precursor acute lymphoblastic leukemia (BPL) respond well to chemotherapy at initial diagnosis; however, therapeutic options are limited for individuals with BPL who relapse. Almost all BPL cells express CD19, and we recently cloned the gene encoding a natural ligand of the human CD19 receptor (CD19L). We hypothesized that fusion of CD19L to the soluble extracellular domain...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci76610